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Thursday, August 6, 2020 | History

4 edition of Protein phosphorylation in cell growth regulation found in the catalog.

Protein phosphorylation in cell growth regulation

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  • 21 Currently reading

Published by Harwood Academic Publishers in Australia .
Written in English

    Subjects:
  • Phosphoproteins -- Physiological effect.,
  • Cells -- Growth -- Regulation.,
  • Protein Kinases -- metabolism.,
  • Cell Division -- physiology.,
  • Phosphorylation.,
  • Phosphoproteins.,
  • Cellular control mechanisms.,
  • Growth factors.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Michael J. Clemens.
    ContributionsClemens, Michael J.
    Classifications
    LC ClassificationsQP552.P5 P77 1996
    The Physical Object
    Paginationviii, 287 p. :
    Number of Pages287
    ID Numbers
    Open LibraryOL116311M
    ISBN 109057020319, 9057020300
    LC Control Number99458449
    OCLC/WorldCa36945405

      Abscisic acid (ABA) is an important phytohormone regulating various plant processes, including seed germination. Although phosphorylation has been suggested to be important, the protein kinases required for ABA signaling during seed germination and seedling growth remain elusive. Here, we show that two protein kinases, SNF1-RELATED PROTEIN KINASE (SnRK) and SnRK, Cited by: Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria. Front. Microbiol. doi: /fmicb Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria. TransitoGarcia-Garcia. 1,SandrinePoncet. 1,AbderahmaneDerouiche. 2,LeiShi. 2, IvanMijakovic. 2,3Cited by:

    Cell surface receptor, directly linked to intracellular enzymes, receptor for most polypeptide growth factors, protein tyrosine phosphorylation, structural organization: Nterminal extra cellular ligand binding domain with one transmembrane alpha helix and a cytosolic Cterminal domain with . The regulation of protein phosphorylation by sphingosine in A human epidermoid carcinoma cells was examined. Sphingosine is a competitive inhibitor of phorbol ester binding to protein kinase C (Ca2+/phospholipid-dependent enzyme) and potently inhibits phosphotransferase activity in vitro. Addition of sphingosine to intact A cells caused an inhibition of the phorbol ester-stimulated Cited by:

      When compared with gene regulation, reversible phosphorylation represents a key, highly flexible mode for AQP regulation (Johansson et al., ; Törnroth-Horsefield et al., ).Yet, its involvement in the diurnal or circadian regulation of tissue hydraulics has remained elusive (Lopez et al., ).We previously demonstrated that phosphorylation of the PLASMA MEMBRANE INTRINSIC Cited by: 4. Protein phosphorylation is controlled by protein kinases and protein phosphatases. A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation). The human genome contains about protein kinase genes, and they constitute about 2% of all human genes.


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Protein phosphorylation in cell growth regulation Download PDF EPUB FB2

Regulation of the activities of some of the proteins involved in transcription and translation has already been discussed in this and the preceding chapter, and many further examples of regulated protein function in the control of cell behavior will be evident throughout the remainder of this book.

This section discusses the three general Cited by: 3. ISBN: OCLC Number: Description: viii, pages: illustrations ; 26 cm: Contents: Receptor and non-receptor tyrosine kinases; protein tyrosine phosphatases in cell growth regulation; role of JAK tyrosine in cytokine signal transduction; mitogen-activated kinases and the control of cell growth; role of the protein kinase C.

Protein kinases and phosphatases play pivotal roles in regulating and coordinating aspects of metabolism, gene expression, cell growth, cell motility, cell differentiation, and cell division. As Protein phosphorylation in cell growth regulation book result, if cellular life is to function in an orderly manner, the switching on and off of protein kinases and phosphatases is as crucial for their function as their catalytic by: Protein phosphorylation is the most abundant form of cellular regulation, organizing essentially all cell functions, including metabolism, proliferation, differentiation, motility, survival and death.

Protein phosphorylation is a post-translational modification of proteins whereby a phosphate group is covalently attached to either a serine. Regulation of protein phosphorylation is frequently disrupted in the diseased state, and protein kinases have become high-profile targets for drug development.

Finally, I consider recent advances on protein kinases as drug targets and describe some of our recent work with CDK9 (cyclin-dependent kinase 9)-cyclin T, a regulator of by:   Regulation of cell division in eukaryotes including higher plants is crucial for growth, differentiation, development, and cell death.

Protein phosphorylation plays a major role in signaling to control the cell division, and is driven by protein kinases called mitotic kinases, including a cyclin‐dependent kinase (CDK), an Aurora kinase, and a mitogen‐activated protein kinase (MAPK).Cited by: 1.

modification by protein phosphorylation could serve a fundamental role in the regulation of cellular processes. We know today that phosphorylation is one of the most prevalent mechanisms of regulation, and it is clear that it. Get this from a library. Reversible Protein Phosphorylation in Cell Regulation.

[R L Khandelwal; J H Wang] -- This book, published in association with the journal MOLECULAR AND CELLULAR BIOCHEMISTRY, is dedicated to Ed Krebs and Eddy Fischer in celebration of their Nobel Prize in Physiology and.

In book: Protein Phosphorylation, pp - subverts the normal regulation of cell growth, which results in oncogenic transformation.

The catalytic activity of the T cell protein. For instance, protein kinase B is only activated follo wing phosphorylation of its Ser and Thr residues and, thus, is able to regulate cell survival ; on the other hand, when proto-oncogene tyrosine-protein kinase (c-Src) is dephosphorylated, it is turned off causing a block in the regulation of cell by: Peroxisomes perform essential roles in a range of cellular processes, highlighted by lipid metabolism, reactive species detoxification, and response to a variety of stimuli.

The ability of peroxisomes to grow, divide, respond to changing cellular needs, interact with other organelles, and adjust their proteome as required, suggest that, like other organelles, their specialized roles are highly Cited by: 3.

Protein Phosphorylation in Cell Growth Regulation by April Clemens. $ Free shipping. P53 PROTEIN: FROM CELL REGULATION TO CANCER (COLD SPRING By Guillermina Lozano.

$ Free shipping. A book that does not look new and has been read but is in excellent Rating: % positive. Reversible Protein Phosphorylation in Cell Regulation (Developments in Molecular and Cellular Biochemistry): Medicine & Health Science Books @ Reversible protein phosphorylation, principally on serine, threonine or tyrosine residues, is one of the most important and well-studied post-translational modifications.

Phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle. The mitochondria are double membrane-bound organelles found in most eukaryotic cells. They generate most of the cell’s energy supply of adenosine triphosphate (ATP).

Protein phosphorylation and dephosphorylation are critical mechanisms in the regulation of cell signaling networks and are essential for almost all the cellular functions.

For many decades, mitochondria were considered Cited by: Hence p53 is a tumor suppressor gene. p53 is usually bound to the protein HDM2 which down regulates its activity by leading to its degradation. Stress signals lead to the activation of protein kinases in the cell (such as p38, JNK, and cdc2), causing phosphorylation of Ser 33 and and Thr 81 in p Cancer and Gene Regulation Cancer is not a single disease but includes many different diseases.

In cancer cells, mutations modify cell-cycle control and cells don’t stop growing as they normally would. Mutations can also alter the growth rate or the progression of the cell through the cell : Lisa Bartee, Walter Shriner, Catherine Creech.

Biochemical Regulation of the CDC2 Protein Kinase G. Draetta Molecular and Biochemical Characterization of the Mitogen- activated S6 Kinase G. Thomas Protein Phosphorylation in the Nervous System M.

Kilimann Mitotic Control in Mammalian Cells, Positive and Negative Regulation by Protein Phosphorylation A. Fernandez and N. Lamb. The Ras–mitogen-activated protein kinase (MAPK) pathway is a key signaling pathway that is involved in the regulation of normal cell proliferation, survival, growth and differentiation.

This pathway includes the whole number of kinases, being regulated through phosphorylation in consecutive by: 8. from book ampk regulation of cell growth, apoptosis, autophagy and bioenergetics (pp) AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics Chapter November with.

Frederickson R., Lazaris-Karatzas A., Sonenberg N. () The Eukaroyotic mRNA Cap Binding Protein (eIF-4E): Phosphorylation and Regulation of Cell Growth.

In: McCarthy J.E.G., Tuite M.F. (eds) Post-Transcriptional Control of Gene Expression. NATO ASI Series (Series H: Cell Biology), vol Springer, Berlin, HeidelbergCited by: 4.Interestingly, Atg1/Unclike kinase 1 is the only protein kinase among the Atg proteins.

InTsukada and Ohsumi reported the isolation of different autophagy-defective mutants of S. cerevisiae [].The apg1 strain was the first identified strain, and subsequently it was discovered that the corresponding gene encodes a serine/threonine protein kinase [], which was subsequently termed by: 3.They are cellular mechanisms that couple energy expense with reversible, allosteric regulation of protein structure and function.

Define Phosphorylation: A COVALENT modification of a SINGLE AMINO ACID SIDE CHAIN (other methods of post-translational covalent amino acid modification are also used by the cell - ex: ubiquitation).